Postdoctoral Research Associate
Department of Systems Biology and Translational Medicine
Education: Hon. B.Sc., Mathematics, 1997, University of Toronto.
Ph.D., Mathematics, 2003, University of Michigan.
Much of the history of mathematics is not concerned with math as a science for
its own sake, but rather with math as a science in service of other disciplines.
Newton developed the differential and integral calculus not for its own inherent
beauty, but for its utility in solving the problems of a physical nature in
which he was interested. The modern trend towards interdisciplinary studies is
returning math, to a certain degree, to this utilitarian paradigm. This may be
especially true in biology, where the reductionist approach is now being
complemented by a systems approach. The data generated by experiments in
the systems mold is often massive and requires careful mathematical and
statistical analysis.
I am interested in applying the analytical skills developed and honed through
an undergraduate and graduate career in pure mathematics, as well as a postdoc
in pure mathematics, to problems of a systems biological nature. As a first
project in my new field (link to project)
I am using a collection of freely available murine microarray experimental data
to construct theoretical gene regulatory networks. The data retrieval phase,
and that of generation of statistics, presented difficulties of a technical
nature. The real interest, however, lies in decisions pertaining to network
construction and the meaning of "significant" and
"relationship". These questions must be addressed both from a
mathematical and a biological perspective. This aspect of the project is
the current focus of my research. With the support of the AHA (Award NUmber:
0825110F), I plan to examine network growth, network topological properties,
from both a top-down and a bottom-up perspective. The aim is to better
understand regulatory networks in cardiac development, and perhaps gain
an understanding of developmental problems and disease.
Our group has several other projects of a bio/mathematical nature to which I
contribute in any way I can, either through discussion, analysis or coding.
Additionally, I have made an effort to start collaborations with other members
of the department, as well those on the more clinical side at the Scott & White
campus. These collaborations now include ongoing work with the Zaweija lab,
as well as Jim Littlejohn in the Department of Surgery.
PAPERS:
StarNet 2.0: A Web-based tool for accelerating discovery of gene regulatory networks using microarray co-expression data. (Daniel Jupiter, Hailin Chen and Vincent VanBuren), submitted.
The upregulation of Bcl-xl by hepatocyte growth factor in human mesothelioma cel ls involves ETS transcription factors (Xiaobo Cao, James Littlejohn, Charles Rodarte, Lidong Zhang, B. J. Martino, Philip Rasco, Kamran Hamid, Daniel Jupiter, Roy Smythe), in press American Journal of Pathology.
TreeHugger: A new test for enrichment of GO terms. (Daniel Jupiter, Jessica Sahutoglu and Vincent VanBuren), in press INFORMS Journal on Computing.
Cluster analysis of hydration waters around active sites of bacterial alanine racemase using 2-ns MD simulations. (Hung-Chung Huang, Daniel Jupiter, James M. Briggs and Vincent VanBuren), in Biopolymers. 89:210-219, 2008. (*Featured on the journal cover.)
A visual data mining tool that facilitates reconstruction of transcription regulatory networks in mouse heart development. (Daniel Jupiter and Vincent VanBuren), in PLoS ONE 3, 2008.
Bcl-xL antisense oligonucleotide and cisplatin combination therapy extends survival in SCID mice with established mesothelioma xenografts. (James Littlejohn, Steven Miller, Mustafa Ozvaran, Daniel Jupiter, Lidong Zhang, Charles Rodarte, Roy Smythe and Xiaobo Cao), in International Journal of Cancer 123:202-208, 2008.
CR Runge sets on hypersurface graphs. (with Albert Boggess and Roman Dwilewicz), in Journal of Geometric Analysis, 18:980-1001, 2008.
A schlichtness theorem for envelopes of holomorphy, in Mathematische Zeitschrift, 253:623-633, 2006. (ArXiv math.CV/0404497.)
Invariant subspaces of RL^1 (with David Redett), in Houston Journal of Mathematics, 32:1133-1138, 2006. (ArXiv math.FA/0409119.)
Multipliers on Dirichlet type spaces (with David Redett), in Acta Scientiarum Mathematicarum (Szeged), 72:179-203, 2006. (arXiv math.FA/0510193.)
Global approximation of CR functions on Bloom-Graham model graphs in C^n (with Albert Boggess), in Proceedings of the American Mathematical Society, 134:723-730, 2005. (ArXiv math.CV/0409120.)
Invariant nonrecurrent Fatou components of automorphisms of C^2, (with Krastio Lilov), in Far East Journal of Dynamical Systems, 6:49--65, 2004. (ArXivmath.CV/0309253.)
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